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KMID : 0620920000320040231
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Experimental & Molecular Medicine
2000 Volume.32 No. 4 p.231 ~ p.234
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Y chromosome microdeletions in idiopathic azoospermia and non-mosaic type of klinefelter syndrome
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Young Tae Kim/Yong Ho Lee
Tak Kim/Mee Hye Kim/Young Tae Kim/Sun Haeng Kim
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Abstract
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The objective of this study was to elucidate the cause of the spermatogenic defect in idiopathic azoospermia and non-mosaic type of Klinefelter syndrome. Genomic DNAs from 9 cases of Korean idiopathic azoospermia and 6 of Korean non-mosaic type of Klinefelter syndrome were used for the detection of Y chromosome microdeletions by polymerase chain reaction using 60 primers. Microdeletions of the Y chromosome were found in 1 of 9 (11.1%) patients with idiopathic azoospermia, whereas none was deleted in non-mosaic type of Klinefelter syndrome. This result suggests that Y chromosome microdeletions could be one of the etiologic factors in idiopathic azoospermia.
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KEYWORD
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Y chromosome, microdeletion, idiopathic azoospermia, Klinefelter syndrome,
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